10 Shocking Dao Supplement Side Effects

Understanding dao supplement side effects is vital especially if you intend to use it over a long period of time and in high dosage.

If you don’t know this, dao is short for diamine oxidase.

It is sold over-the-counter in synthetic forms to supplement the diamine oxidase enzyme naturally produced by the body.

This supplement breaks down foods rich in histamine and may help you manage symptoms of histamine intolerance.

Without enough of diamine oxidase, you can get sick if you eat foods rich in histamine.

As vital as this supplement may be, there are some dao supplement side effects that we should take about more.

But first, below are a few things it helps with.

Benefits of dao supplement

Despite the several dao supplement side effects, it also has a lot of benefits, such as the one discussed below.

Reduces headaches and migraines

Dao supplement can help reduce the frequency of your headaches or migraines.

Additionally, it can lower the length of your headache or migraine attacks by as long as 30 minutes.

Eases some skin conditions

Dao supplements can help relieve symptoms of hives.

People with low levels of dao who take these supplements can take lower doses of antihistamine medication.

Relieves digestive symptoms

If you have histamine intolerance, taking dao supplements can help relieve your digestive issues.

It can heal your digestive lining, making you experience fewer and less painful digestive symptoms.

How do I know if I have dao deficiency?

Genetic alterations, the consumption of certain medicines, or diseases can cause Dao deficiency.

Most patients with reduced dao activity experience headaches, migraines, constipation, diarrhea, soft tissue pain, bloating, and chronic fatigue.

It can also cause asthma, wheezing, and Attention Deficit Hyperactive Disorder (ADHD) in children and adolescents.

How can I increase my dao naturally?

You can increase the amount of dao in your body naturally by taking vitamin supplements, eating proteins that support the production of dao, and balancing your fat intake.

Making an effort to improve your gut health can also help your body generate more of this enzyme.

You can do this by taking probiotics low in histamine, which then support your gut bacteria to help increase dao in your body.

Does caffeine block dao?

In theory, yes, it does.

Caffeine can block the effects of dao and prevent it from breaking down histamine from your food.

This leads to a histamine buildup in your system, which puts you at risk of experiencing intolerance.

If you want to avoid intolerance symptoms, stay away from coffee or switch to quality decaf instead.

Dao supplement side effects

dao supplement side effects

1. May Cause fibrosing colonopathy

This is a rare but serious condition of the bowel that causes scarring and localized inflammation in the large intestines.

The excess use of digestive enzymes in the body can cause it.

A few of its symptoms include vomiting, stomach upset, diarrhea, stomach pain, and constipation.

Using dao supplements can expose you to the risk of developing this condition.

2. Changes in blood sugar

Being a digestive enzyme, dao supplement can increase the speed at which your body breaks down carbohydrates, causing a spike in your blood sugar.

If you are watching your blood sugar, make sure you talk to your doctor before you decide to start taking the dao supplement.

3. It may cause thinning of the blood

Taking dao supplements during or after surgery is not a very good idea; it can increase the risk of bleeding by preventing platelet coagulation.

An example of an anticoagulant that may interact with dao supplement is Warfarin.

Similarly, you should use it cautiously if you are already taking blood thinners.

4. May interfere with diabetes medication

If you are taking medication for diabetes, like Miglitol and Acarbose, do not use this supplement before consulting your doctor.

It may interfere with the effectiveness of your medication.

5. Esophageal perforation

Esophageal perforation is one of the scariest dao supplement side effects.

Put simply, esophageal perforation happens when your oesophagus is torn.

It has several causes, including foreign objects, severe vomiting, and surgical injuries.

However, in rare cases, it can be caused by excess digestive enzymes in your body.

Taking dao supplement in excess puts you at a slight risk of experiencing tears in your esophagus.

If you suffer from hiatal hernia or gastroesophageal reflux disease (GERD), you are at a greater risk of experiencing these tears.

6. It may cause cramping

Taking digestive enzymes like dao supplement in excess may cause you to experience abdominal cramps.

If you feel pain in your abdomen while using any supplement of dao, the supplement may be responsible for your pain.

7. Difficulty in breathing

You may develop respiratory problems as a result of using dao supplement.

A few of these problems include difficulty breathing, chest tightness, and wheezing.

If not treated, these symptoms could turn into something more severe.

Should you experience any such issues while using dao supplements, be sure to talk to your doctor for a better alternative.

8. Changes in bowel movements

There’s a good chance that digestive enzymes like dao will cause undesirable changes in your bowel movements.

You may experience stomach upset, bloating, flatulence and diarrhea when taking this supplement.

9. Skin reactions

It is possible to experience skin reactions like itching, reddening, blisters, and peeling when using this supplement.

You can talk to your doctor to help you eliminate these symptoms and figure out a less harsh alternative for your diamine oxidase supplementation.

10. Drowsiness

You may experience a bit of drowsiness after taking dao supplement because it has a sedative effect on some people.


Most reviews fail to reveal dao supplement side effects, which is a bit dangerous considering there’s more to this product than meets the eye.

Thankfully, this article reveals most of the dao supplement side effects you should be aware of as a user.

It also tells you some of its benefits, so you know what it can help you despite its shortcomings.

If you are prone to any dao supplement side effects, have a word with your doctor before you take it.

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